In summary, we have found that a SNP (rs3800779, c.307+585G>T) located on HERG1 shows significant differences in both genotype and allele distributions between patients with SCH and control subjects, and we have also identified two previously undescribed four-marker haplotypes located on 7q36.1 region in chr7:150225599-150302147 bp position encompassing HERG1 and more significantly associated with SCH than individual SNP (the at-risk haplotype A-A-A-T and the protective haplotype C-A-C-G, which are nearly allelic opposite of each other). This evidence concerns the gene KCNH2 and spindle cell hemangioma.