KCNH2 and spindle cell hemangioma: With regard to our second inference, the A-A-A-T/C-A-C-G haplotypes may also signify the contribution of CNV 3711, which is partly inserted into HERG1 (~21.5 kb from its 3'-end, Figure 4a), to the pathogenesis of SCH by affecting gene expression, which is a well-known mechanism of CNVs [57,58].