DVL1 and breast cancer: The levels of Wnt pathway components, which are common to both the canonical and noncanonical pathways, are altered more often; Dvl1 is upregulated in 50% of ductal breast cancer cases [42], and sFRP1 - a soluble Wnt antagonist that can block both Wnt/β-catenin and noncanonical pathways - is repressed in more than 80% of breast carcinomas [43].