In children with definite or probable TB and a positive IFN-γ ELISpot at presentation, paired analysis of IFN-γ responses showed a statistically significant increase in IFN-γ responses to PPD at six months (p = 0.02), decrease in IFN-γ responses to ESAT-6 at two months (p = 0.01) and decrease in IFN-γ responses to CFP-10 at two (p = 0.03) and six months (p = 0.02). This evidence concerns the gene IFNG and tuberculosis.