AIP and acromegaly: In Family 10, two AIP changes were identified in two asymptomatic male carriers (70 and 65 years): the c.910C > T, p.R304X (a known pathogenic mutation) [Leontiou et al., 2008] and the c.896C > T, p.A299V (previously reported in a patient with sporadic acromegaly [Georgitsi et al., 2007], but in none of the general population subjects studied by us or others) variants.