Interestingly though, associated LRRK2 pathology comprises variable lesions; (diffuse) LBs and/or PSP-like tau aggregation or none of the above [Zimprich et al., 2004a], suggesting that LRRK2 dysfunction might be an upstream event in neurodegeneration and causing disturbances in different pathways. This evidence concerns the gene LRRK2 and supranuclear palsy, progressive, 1.