On the other hand, isolated studies have also reported LRRK2 mutations in carriers with a clinical diagnosis of sporadic PD with late-onset AD as well as CBD, PSP, or frontotemporal dementia (FTD) [Chen-Plotkin et al., 2008; Santos-Reboucas et al., 2008; Spanaki et al., 2006]. This evidence concerns the gene LRRK2 and Parkinson disease.