Also, the two subpopulations isolated from patient biopsies did not show significant differences with respect to tumourigenic abilities: 1000 cells from ALDH+ and ALDH− formed tumours at 7 of 12 (58%) and 6 of 11 (55%) sites, respectively; 500 cells failed to induce tumours (0/4) in both cases during 6 months in vivo. The gene discussed is LDHA; the disease is neoplasm.