Indeed, a neutralizing anti-IL-8 antibody has significantly reduced ischemia-induced brain damage [66], further suggesting that inhibition of IL-8 binding to its receptor CXCR1 is another potential target for inhibiting the IL-8 effects [68], and the decreased CXCR1 expression may play a neuroprotective role. The gene discussed is CXCR1; the disease is ischemia.