HOXB13 and posterior cortical atrophy: Overall, hormone-refractory tumors showed significantly stronger expression of HOXB13 than androgen dependent tumors (Pearson's = 11.2707, p = 0.0008) (Figure 2C), suggesting that HOXB13 expression is somehow altered, or that high HOXB13 expressing cells are selected during androgen-independent progression of PCa.