An example of an aberrantly expressed miRNA influenced by p53 in fludarabine-refractory CLL has been recently reported by Zenz and colleagues, who observed a higher frequency of fludarabine refractory CLLs in the group of low-expressing miR-34a, than in similar patients with high expression of this miRNA [30]. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.