SOD2 and cancer: Among the recently validated targets there are the BH3-only pro-apoptotic protein BMF [33], the cell adhesion molecule ICAM-1 [34], matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2), which are both involved in tongue carcinoma metastasis promotion [35] and whose expression is frequently altered in cancer.