In addition, TF expression was only detected by both mfVII/hIgG1 Fc Icon and anti-TF antibody on VEGF-stimulated HUVECs but not on unstimulated HUVECs (Figure 2B), indicating that TF is specifically expressed on angiogenic VECs, such as those in the tumour neovasculature of human breast cancer from patients [1] and human melanoma tumor xenografts from mice [2]. This evidence concerns the gene TF and melanoma.