TF and neoplasm: We showed that fVII-tPDT at 2 μM VP and a light dose of 36 J/cm2 killed almost 90% of VEGF-stimulated HUVEC cells (Figure 3D), which represent angiogenic tumour VECs in pathological angiogenesis, but had no effect on unstimulated HUVEC cells (Figure 3D) (P < 0.001 at all three VP concentrations for VEGF-stimulated vs. unstimulated by two-way ANOVA), which do not express TF and represent normal VECs (Figure 2B).