Although hyperphosphorylated tau is known as the major component of NFTs in Alzheimer's disease, we did not observe signals when immunohistochemistry was performed on the cerebellum of nur17 mice using anti-hyperphosphorylated tau antibodies (data not shown), indicating that NFTs in nur17 mice may not contain hyperphosphorylated tau. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.