Therefore, only slow, classical MHC I cross-presentation, (efficiently functional in human skin-resident epidermal Langerhans DC (L-DC) [177], [178], dermal DC (d-DC) [179] and other immune and parenchymal cells [180] such as traversed [181] skin or malaria-infected liver cells [111], [182]), is available to generate protective cytotoxic (CD8+, MHC I) responses to malaria antigens presented at the skinstage [18], [28], [183], [184] in humans. Here, CD8A is linked to malaria.