This directly infers IL-6 blockade by malarial CSP [301] prevents immediate protective T cell activation and memory responses in the skin, LN and infected hepatocytes, simultaneously stimulating in these locations antigen-specific Treg formation [303], [304], [305], [306], [310], [311] and expansion [305], triggered by malaria antigens. The gene discussed is DNAJC5; the disease is malaria.