IRF3 and infection: Infection of the Cm3′ virus exhibited little IFN-β induction and dsRNA generation, although it has lost the ability to inhibit poly(I:C)-mediated translocation of IRF-3 into the nucleus, supporting above-mentioned relationship between viral abilities to generate dsRNA and to induce IFN-β, and suggesting that the viral dsRNA might be a major trigger of host innate immunity.