Although a relationship between FTO polymorphisms and obesity has been found in African-American children [11], there was no association between FTO variants and either diabetes or obesity in a study of postmenopausal women [12], and there have been inconsistent results for African-American adults in three other family-based studies [8], [13], [14]. The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.