Infection of macrophage/neutrophil-specific (LysMcreIl4ra−/lox) and T cell-specific (iLckcreIl4ra−/lox) IL-4Rα-deficient mice showed these mice to have high mortality during acute schistosomiasis irrespective of granuloma formation [6], [10]. This evidence concerns the gene IL4R and schistosomiasis.