TP53 and squamous cell carcinoma: This finding is consistent with the recent data for two non-small-cell lung cancer cell lines, NCI-H460 and A549 (Koll et al, 2008), but it conflicts with the results for squamous carcinoma cell lines (Shintani et al, 2006), indicating that the Hsp90 inhibitor 17-AAG is a more efficient radiosensitiser in a cell line with p53 wild type compared with four p53-mutated cell lines.