BRCA2 and prostate carcinoma: The authors suggest that 17DMAG inhibits the repair of DNA DSBs induced by radiation (Dote et al, 2006), Similarly, an inhibition of homologous DNA recombination repair, that is, degradation of BRCA2 and alteration of Rad51 by 17-AAG, causes the radiosensitisation of prostate carcinoma DU145 and lung squamous carcinoma SQ-5 cell lines (Noguchi et al, 2006).