PTEN and metastatic malignant neoplasm in the lymph nodes: The multivariate Cox regression analysis for LRC showed that PTEN (HR: 2.2; 95% CI: 1.1–4.6), extranodal spread (HR: 2.7; 95% CI: 1.2–6.5) and the presence of lymph node metastasis (HR: 5.7; 95% CI: 1.2–27.4) were all independent prognostic factors for LRC.