The results of studies investigating major histocompatibility complex (MHC) polymorphisms and cervical cancer susceptibility in different populations have been inconsistent,13–27 and most studies of HLA and cervical cancer have focused on HLA class II alleles.18–22 Although the importance of CTL responses to viral infection and tumor regression are well recognized, few studies have investigated HLA class I alleles.24–27. The gene discussed is HLA-C; the disease is cervical cancer.