Finally, while our results could indicate that SOCS3 is more important in the underlying pathogenesis of inflammation-associated rather than sporadic CRC, recent studies comparing SOCS3 expression in both ulcerative colitis-associated and sporadic tumors found that SOCS3 was decreased and there was no significant difference between the two groups for SOCS3 [2]. The gene discussed is SOCS3; the disease is ulcerative colitis.