TLRs are likely to play a complex role in RA, and certain TLRs exhibit a high expression, such as TLR2, 3, 4, 7 in synovium [12-15], TLR3 in fibroblast-like synoviocytes (FLS) [14], TLR2, 4 in CD14+ macrophages and peripheral blood cells from RA [16]. This evidence concerns the gene CD14 and rheumatoid arthritis.