This hypothesis is further supported by our finding of a close inverse correlation of ghrelin with serum glucose (r = -0.369, P = 0.018) and insulin (r = -0.406, P = 0.019) as important markers of carbohydrate metabolism in non-sepsis patients at admission to the ICU (Figure 3b, c), but not in sepsis patients. This evidence concerns the gene INS and Sepsis.