Specifically, ghrelin was found to mediate improvement of tissue perfusion in severe sepsis [11], down-regulation of proinflammatory cytokines in sepsis through activation of the vagus nerve [12], stabilization of gut barrier function in sepsis [13], attenuation of sepsis-induced acute lung injury [14] and protection against endotoxemia-induced acute kidney failure [15]. This evidence concerns the gene GHRL and Sepsis.