Furthermore, few clinical cases of ARHR have been reported so far; therefore, it is challenging to obtain human cases for pathophysiologic studies.(12,13,15) Thus generation of DMP1 mutant mouse models based on the human mutations is critical not only for distinguishing these differences but also for molecular pathophysiologic studies of this disorder. The gene discussed is DMP1; the disease is autosomal recessive hypophosphatemic rickets.