TNFSF11 and Camurati-Engelmann disease: This TNFSF11 change was not found in dbSNP(26) and was not reported in several association studies of RANKL single-nucleotide polymorphisms (SNPs) with bone phenotypes.(27,28,53) However, we identified this RANKL variant in 4 of 67 heterozygous patients (or family member) with various bone diseases and 1 homozygous patient with a unique variant of Camurati-Engelmann disease,(29) but a healthy population has not been screened.