AKT1 and squamous cell carcinoma: These observations are consistent with the findings of Shepler's group that there is frequent EGFR amplification and MAPK and Akt phosphorylation in conjunctival squamous cell carcinomas; of Chen and colleagues and Kohrenhagen's group that increased expression of p-MAPK and p-Akt appeared during tumor progression of cervical neoplasms [25]–[27].