There is molecular evidence that viral oncoproteins (E5, E6 and E7) found in high-risk HPV genotypes inactivate the tumor suppressor proteins p53 and pRb, promote genomic rearrangement, and confer replicative and immortalizing activities in cervical neoplasms, conjunctival squamous cell carcinoma and other cancers [12], [13], [30], [31]. This evidence concerns the gene ARHGEF15 and conjunctival squamous cell carcinoma.