Furthermore, the effects of MGBs on DNA-protein interactions were characterized and revealed that HMGA1-DNA binding is critical for full induction of the P-selectin promoter, and, moreover, that inhibition of HMGA1-DNA binding in vivo at a novel AT-rich DNA site within the P-selectin promoter correlates with attenuated inflammation during murine endotoxemia. The gene discussed is HMGA1; the disease is serum lipopolysaccharide activity.