PCSK1 and obesity due to melanocortin 4 receptor deficiency: Similarly, another recent study in 20,249 individuals of European descents from Norfolk, UK, also failed to replicate the association of the PCSK1 rs6235 with obesity and related traits, and only found a suggestive evidence for association of the PCSK1 rs6232 with obesity and BMI in younger individuals (age <59 yrs) but not in older age group [7].