An assessment of 3 other mammalian cell lines (COS1, HEK293 and HK2) revealed all of them to express SEDLIN (Figure 5B), and as SEDLIN-null cell lines are not available from SEDT patients or a mouse model, we further explored the effects of mutant SEDLINs on the interaction with the transcription factors MBP1, PITX1 and SF1, in yeast cells. Here, ENO1 is linked to spondyloepiphyseal dysplasia tarda, X-linked.