HTT and frontotemporal dementia: Spinal cord homogenates from Tg20 mice infected with the RML strain of prions [30], huntingtin transgenic mice (N171-82Q) [31], and human brain homogenate from frozen post mortem material of a patient who died with frontotemporal dementia from a CHMP2B mutation (FTD3 [32]) were used as seeds in the same in vitro fibrillization assay.