HMBOX1 and neoplasm: There are data on the role of high mobility group box 1 (HMBOX1) protein in reporting cancer cell death to the immune system as an essential part of tumor death by chemotherapy agents [16], and findings showing that AP2L/TRAIL (tumor-necrosis-factor-related apoptosis induced ligand) binding to “death receptors” DR4 and DR5 induces selective tumor cell apoptosis via the external apoptosis pathway [17]–[19].