We thus used our approach to identify genetic interactors of the Rab-specific guanine-nucleotide dissociation inhibitor gdi-1 (WormBase: WBGene00001558) which shares 80% protein sequence identity with GDI1 (Ensembl: ENSG00000203879; Blast E-value: 2.10×10−158), a gene associated with non-syndromic forms of mental retardation in human (OMIM: 300104) [5]. Here, GDI1 is linked to Intellectual disability.