LMNA and Hutchinson-Gilford progeria syndrome: This is further supported by evidence of abnormalities in heterochromatin organization in cells from laminopathic patients, which are well documented in cells from patients with Hutchinson-Gilford progeria syndrome (HGPS), an inherited disease arising from a splicing defect in pre-lamin A [9]–[14], and those with mandibuloacral dysplasia type A (MAD-A) due to a R527H mutation in LMNA[15].