EMD and Alzheimer disease: By transient transfection of C2C12 cells with Flag-tagged lamin A mutants, Östlund et al. found that a sub-set of mutants, including several AD-EDMD-linked mutants, was dramatically mislocalized in many cells, but that all AD-EDMD mutants containing a mutation within the Ig-fold, and in particular the R453W mutant, showed no localization abnormalities.