Since most laminopathy-associated LMNA mutations are inherited as dominant traits, point-mutant specific antibodies would allow for the first time to study in patient cells potential alterations of the mutant protein, such as sub-cellular localization, protein interactions, or post-translational modifications, a task, for which so far no research tools have been available that could distinguish the point-mutant from the wild-type protein. This evidence concerns the gene LMNA and laminopathy.