Briefly, biallelically expressed genes, -- such as TP53, AML1, RB1, C-MYC and HER2 (which normally display a synchronous mode of replication) -- exhibit an asynchronous pattern of replication (similar to that of monoallelically expressed genes) in bone marrow cells [15] and blood lymphocytes [16] of patients with hematological malignancies, and even in blood lymphocytes of patients with solid tumors, such as renal cell carcinoma [7] or prostate cancer [8,17]. Here, RUNX1 is linked to Familial prostate cancer.