IGHE and asthma: Although high concentrations of aerosolized endotoxin have been recognized as a cause of lung disease in cotton (textile) workers (Castellan 1995) and swine handlers (Vogelzang et al. 1998), recent interest has focused on the complex role of nonoccupational indoor and outdoor endotoxin concentrations in the occurrence of immunoglobulin E (IgE)–mediated allergy and asthma (Koppelman et al. 2001).