Further studies are necessary to elucidate (i) whether another case-control study is appropriate and (ii) whether promoter SNPs can affect the expression of WNT2. To confirm or refute the lack of association between the WNT2 gene and schizophrenia, replication studies with adequate sample sizes, or studies with additional SNPs not analyzed in the present study, may be required. The gene discussed is WNT2; the disease is schizophrenia.