ESR1 and chronic myelogenous leukemia, BCR-ABL1 positive: The methylation of several tumor suppressor genes (TSGs) including E-cadherin, death-associated protein kinase (DAPK), estrogen receptor (ER), and the cell cycle regulating genes (P15INK4B and P16INK4A), has been confirmed associated with the development and progression of CML [6-9].