In the meantime, 53 episodes of bacterial infections were diagnosed in patients who had early discontinuation of primary prophylaxis, yielding an incidence rate of 14.48 per 100 PY (95% CI, 10.85 to 18.94), while 13 episodes were diagnosed in the patients who discontinued primary prophylaxis after CD4 counts increased to ≧200 cells/μL, yielding an incidence rate of 5.56 per 100 PY (95% CI, 2.96 to 9.50) (P < 0.001). The gene discussed is CD4; the disease is bacterial infectious disease.