In total, 21 episodes of bacterial infections were diagnosed in patients who had early discontinuation of secondary prophylaxis, yielding an incidence rate of 8.71 per 100 PY (95% CI, 5.39 to 13.32); and 7 episodes were diagnosed in patients who discontinued secondary prophylaxis after CD4 counts increased to ≧200 cells/μL, yielding an incidence rate of 3.33 per 100 PY (95% CI, 1.34 to 6.87). Here, CD4 is linked to bacterial infectious disease.