It was observed that attenuation of CXCR4 with either the blocking mAb, MAB172 or the antagonist, AMD3100 led to statistically significant attenuation of breast cancer cell migration in response to SDF1α in MCF7 (Figure 3A) and MDA-MB-231 (data not shown) cells. Here, CXCL12 is linked to breast carcinoma.