Sepsis (odd ratio 5.24), among the clinical variables and IL-10 (odd ratio 1.24, 95% confidence interval (CI): 0.00–2.19) and transferrin (odd ratio 0.45, CI: 0.00–6.43) among the stress and nutritional mediators were independently associated with the development of MOSF (P < .0001). This evidence concerns the gene TF and Sepsis.