When a multiple linear regression analysis (stepwise method) was used, classified sepsis (r2 = 0.25, P = .003), transferrin (r2 = 0.21, P = .01), IL-6 (r2 = 0.31, P = .002), and the NI (r2 = 0.52, P = .001) were independently associated with the PRISM score (F = 12, P = .0000). The gene discussed is TF; the disease is Sepsis.