TGFB1 and neoplasm: The TGF-β superfamily consists of over 30 structurally related multifunctional proteins, including three TGF-β isoforms (TGF-β1, 2, and 3), three forms of activin, and over 20 bone morphogenic proteins (BMPs), which control a broad range of cellular behavior such as cell growth, differentiation and apoptosis in various cell types including tumor, immune, and endothelial cells as well as fibroblasts [1–5].