Fujita et al. observed similar results using plasmid DNA encoding the extracellular domain of the TGF-β type II receptor fused to the human IgG heavy chain; after plasmid injection in the proximity of established murine lymphomas an increased number of tumor antigen-specific CD4+ and CD8+ cells could be detected in tumor-draining lymph nodes [105]. Here, CD8A is linked to neoplasm.