CGB5 and renal carcinoma: At the genomic level, activation of transcription of CGB, CGB5 and CGB8 genes has been associated with malignant transformation of non-trophoblastic cells (breast, bladder, prostate, thyroid, testis and renal cancer) (Bellet et al., 1997; Giovangrandi et al., 2001; Hotakainen et al., 2007).