Among the three common synonymous changes described in the coding region of FSHB, the 2623T>C (Tyr58Tyr) in exon 3 has been demonstrated to be more frequent among obese patients with polycystic ovary syndrome (PCOS) than in healthy females (Table 3; Fig. 3; Figure S1) (Tong et al., 2000). Here, FSHB is linked to polycystic ovary syndrome.