EGF and cancer: Lanuti et al. [41] found that the association between EGF +61A/G and esophageal adenocarcinoma risk in earlier-stage patients might suggest that the G/G genotype was associated with a less aggressive phenotype, paralleling lung cancer where individuals with EGF pathway driven tumors seem to have fewer molecular alterations [42,43]; Consider the different allele frequency between Asians and Caucasians, further studies are needed to explore the role of EGF +61 G/A polymorphism in cancer development in different populations.