Vishnoi et al. [33] found that G/G genotype of EGF +61A/G was significantly associated with increased gallbladder cancer risk by examining 126 gallbladder patients and 190 healthy controls; Goto et al. [34] found no association between EGF +61 G/A and gastric cancer but that EGF +61 A/A genotype showed a trend of protection by research on 202 patients and 454 healthy controls. Here, EGF is linked to gallbladder cancer.