Cancer incidence in the PMS2 mutation positive families includes, in order of frequency (in how many families the cancer can be seen): CRC (6 families); lung, stomach and brain cancer (2 families); endometrial + breast cancer, and ovarian + breast cancer (1 family); breast, cervical, Merkel cell and small intestine cancer (1 family). This evidence concerns the gene PMS2 and colorectal carcinoma.