With respect to the TNM tumor staging adenocarcinoma with positive expression of CD133 was 28.8% (19 out of 66) at stage I, 49.4% (38 out of 77) at stage II, 66.7% (98 out of 147) at stage III and 82.6% (38 out of 46) at stage IV, respectively. This evidence concerns the gene PROM1 and neoplasm.