ZNF2 and cryptococcosis: Because Cryptococcus hyphae are rarely observed in human or animal tissues [37], [89]–[94], and the host conditions suppress hyphal growth, it is possible that cells locked in the yeast form, either naturally or by genetic manipulation (e.g. deletion of ZNF2), will show enhanced virulence in animal models of cryptococcosis, whereas cells locked in a filamentous form would be avirulent.