Given the variable expression patterns, known and inferred physiological functions, and likely role of MAP2K6, CCD46, and MTAP in tumor cells, it is a priority to determine whether the differential microarray gene expression patterns that were observed in a larger number (n = 40) of additional MPM samples can be replicated in additional samples and linked to any of the genomic disruptions observed in the current study. This evidence concerns the gene MAP2K6 and neoplasm.