For instance, the Huh7.5 cells, which were cloned from the hepatoma Huh7 cells for their efficacy to support HCV replication [11], are unable to stimulate IFN induction because of a T55I substitution in the first CARD domain of RIG-I that prevents the association of RIG-I with MAVS [5]. Here, IFNA1 is linked to hepatocellular carcinoma.