BACE1 and infection: In A. caninum, double and a single SCP-domain ASPs, called Ac-ASP-1 and Ac-ASP-2, respectively, were identified as major components of ES from serum-activated, infective L3s and proposed to be secreted in response to one or more host-specific signals during the infection process [80], [81], as also hypothesized in a transcriptomic analysis of serum-activated L3s [19].