In multivariate analysis, BRAF mutation and tumour grade were emerged as independent prognostic factors for reduced PFS (HR 2.8, 95% CI 1.4–5.7, P=0.004 and HR 2.0, 95% CI 1.3–3.2, P=0.001 respectively) and OS (HR 5.3, 95% CI 2.5–11.3, P<0.001 and HR 2.6, 95% CI 1.6–4.4, P<0.001 respectively). The gene discussed is BRAF; the disease is neoplasm.