In addition, univariate analysis showed significant associations between OS and (1) tumour differentiation (grade 3) (PFS and OS: P<0.001); (2) BRAF mutations (P<0.0001), (3) metastasectomy (OS: P=0.03) and (4) the sum of treatment lines that a patient had the opportunity to receive (P=0.02). Here, BRAF is linked to neoplasm.