Similarly, it has been reported that in CRC cells the decreased expression levels of pERK protein and cyclin D1 were more pronounced in cells carrying the BRAF V600E mutation, and, that BRAF V600E–ERK signalling is also important in the regulation of proliferation by p27Kip1 and cyclin D1 proteins in these cells (Preto et al, 2008). Here, BRAF is linked to colorectal carcinoma.