The physiological properties of the TTX-resistant persistent current associated with Nav1.8, which include a broad overlap between activation and steady-state inactivation centered close to resting potential, suggest that Nav1.8 contribute a depolarizing influence to resting potential[13], which in some cases, lead to a spontaneous manner of fire in the absence of stimulation which probably contribute to the maintenance of cancer pain. This evidence concerns the gene SCN10A and cancer.