Western blotting (Fig. 2B) revealed a significant decrease in relative Nav1.8 protein levels (percentage of normal) in bilateral DRG of tumor-bearing rats (65.6 ± 4.9 and 78.2 ± 5.4 for ipsilateral and contralateral respectively) compared to the sham group (P < 0.01). Here, SCN10A is linked to neoplasm.